Many epithelial cells also express the vitamin D metabolizing enzyme CYP27B1 which enables autocrine generation of 1,25D from the circulating vitamin D metabolite 25-hydroxyvitamin D (25D), critically linking overall vitamin D status with cellular anti-tumor actions. Consistent with this concept, activation of VDR by its ligand 1,25-dihydroxyvitamin D (1,25D) triggers comprehensive genomic changes in epithelial cells that contribute to maintenance of the differentiated phenotype, resistance to cellular stresses and protection of the genome.
The vitamin D receptor (VDR) is highly expressed in epithelial cells at risk for carcinogenesis including those resident in skin, breast, prostate and colon, providing a direct molecular link by which vitamin D status impacts on carcinogenesis. When the couple is forced to revisit memories of their past, and the thought of losing each other too real, will the couple find their way back to each other or is this truly the end of their love story.Epidemiologic data suggest that the incidence and severity of many types of cancer inversely correlates with indices of vitamin D status. To add insult to injury, Olive is forced to leave her children and travel with her soon-to-be ex-husband to finalize the death certificate on their marriage. With his back against the wall, Nigel sets the separation process into motion, which activates a prenuptial agreement like no other.Ĭonfused and shattered when Nigel files for divorce, a devastated Olive wonders how she got to this point with a man that vowed to love her forever-a man she’d never thought would ever leave her. Nigel Goodwin is at the end of his rope and resolves to take desperate measures into his own hands by doing the one thing he thought he’d never do- file for divorce. With fifteen years of marriage, three children, great jobs, and a home, Olive and Nigel never thought they’d be a couple in distress.
College sweetheart’s Olive and Nigel Goodwin shared a love that was envied by many- a love that levels couldn’t explain.
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